PHILADELPHIA — Hepatitis C virus
infection was detected in solid organ recipients after transplantation,
despite negative pre-transplant nucleic acid testing (NAT), according to data
presented at IDWeek 2014.
Researchers analyzed organ donor and
recipient medical records to determine how common donor-derived
transmissions of hepatitis C virus infection and antibody were, after
the Center for Disease Control and Prevention was notified in January
2014 of two organ recipients testing positive for HCV post-transplant.
Six organ recipients who received seven solid organs were reviewed.
Three of the recipients tested positive for HCV,
which had been undetectable in pre-transplant serum; two patients were
not infected with HCV; and one patient was positive for HCV before
undergoing liver transplantation.
HCV was discovered through stored serum samples and splenocytes at less
than 15 IU/mL and 58 IU/mL. Of the three infected patients, two had HCV
genotype 1a, were negative for anti-HCV and displayed normal liver
function, whereas the third infected recipient died a short time after
transplant. The one patient who died had HCV serum levels less than 15
Labels: IDWeek 2014, post-transplant recurrence