A hinge in the RNA genome of the virus that causes hepatitis C
works like a switch that can be flipped to prevent it from replicating
in infected cells. Scientists have discovered that this shape is shared
by several other viruses—among them one that kills cancer cells.
That's Seneca Valley virus, which seems harmless to healthy human cells but lethal to cancer stem cells.
"Clearly we'd like to understand it better," said Thomas Hermann,
professor of chemistry and biochemistry at the University of California,
Hermann's research group has determined the molecular structure of
this critical switch in the Seneca Valley virus and found that it
matches the L-shaped switch in hepatitis C virus, which his group had previously described.
Labels: IRES, Research and Discoveries