Hepatitis C: What Therapy this Week?

“We really have entered this new era of direct acting antivirals, and as of this fall, we’ve finally laid to rest Interferon in the grave that we’ve all been wanting to put it in, for more than 2 decades,” opened Jacqueline G. O’Leary, MD, MPH, AGAF during her presentation at the 2015 AGA Clinical Congress of Gastroenterology & Hepatology.

According to O’Leary, sofosbuvir certainly changed everything – a truly pangenotypic polymerase inhibitor (NSSB) prescribed as 400 mg daily, never modified with no significant food effect reported. It had recently been co-formulated with ledipasvir, the first in class NSSA inhibitor, once daily dose, and also with no existing food effect.

Switching gears, O’Leary discussed the other FDA approved all oral regiment of paritapevir with ombitasvir and dasabuvir, for their genotype 1 patients. “This is a trick from HIV that allows lower dosing in medication, a dramatic increase in half-life, which adds an additional protection. This is binding against the thumb blood site, which definitely gets two thumbs up, because it allows you to give the finger to hepatitis C.”

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