Evidence of sexual acquisition of hepatitis C virus (HCV) among men who
have sex with men (MSM) receiving pre-exposure prophylaxis through a San
Francisco clinic has prompted a call for routine monitoring for the
virus among PrEP users. In a letter to the editor in Clinical Infectious
Diseases, clinicians from Kaiser Permanente San Francisco Medical
Center describe new cases of hep C among two men out of 485 HIV-negative MSM receiving PrEP at the clinic between February 2011 and December 2014.
the infections occurred during 304 person-years of follow-up, the hep C
incidence rate was 0.7 per 100 person-years. This infection rate is
lower than those observed among populations of HIV-positive MSM in
published research. But the two cases add evidence to previous findings
that the risk of sexual transmission of hep C is likely not reserved to
those who are living with HIV. Additionally, however small the risk of
hep C may be, its existence adds to the larger dialogue about having sex
without a condom while on PrEP (or not on it, for that matter).
Labels: MSM, PrEP, sexual transmission