New research from the University of
Southampton has identified how changes in the cell membrane play a
pivotal role in how the Hepatitis C virus replicates.
By understanding this process, the researchers hope to
investigate how to prevent the changes and potentially develop
therapeutic drugs to combat the Hepatitis C virus (HCV), which infects
an estimated 170 million people globally.
When HCV infects a cell it uses one of its proteins, NS4B, to form a
lipid-rich structure called the 'membranous web'. This structure
contains 'reaction centres', where the virus can replicate protected
from the host cell's antivirus defences.
"Interaction between the NS4B amphipathic helix, AH2, and charged lipid
headgroups alters membrane morphology and AH2 oligomeric
state—Implications for the Hepatitis C virus life cycle," Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1848, Issue 8, August 2015, Pages 1671-1677, ISSN 0005-2736, dx.doi.org/10.1016/j.bbamem.2015.04.015
Read more at: http://phys.org/news/2015-05-scientists-crucial-hepatitis-virus-replicating.html#jCp
Labels: NS4B amphipathic helix, Research and Discoveries