100% SVR4 - HCV Genotype 1 - AbbVie Study - Alan Franciscus

100% SVR4 in HCV Genotype 1 Non-Cirrhotic 
Treatment-Naïve or-Experienced Patients With the Combination of ABT-493 and
ABT-530 for 8 Weeks (SURVEYOR-I)—F Poordad et al.   
Source:  The Liver Conference - AASLD Late Breaker - 14

Results and Conclusions
Thirty-four patients were enrolled in the study—56% were male, 97% white, 71% genotype 1a; 15% had an F3 fibrosis stage at baseline, and 15% were treatment experienced. This was the data from Part 2 of the SURVEYOR-I study, which evaluates the combination of ABT-493 and ABT-530 of treatment of 8 weeks in non-cirrhotic patients with genotype 1. Eighty-five percent of the patients were treatment-naïve (never treated) and 15% had been previously treated with pegylated interferon. The patients were treated with once-daily 300 mg ABT-493 plus120 mg ABT-530 for eight weeks.  About 1/3 of patients had HCV RNA, or viral load was above 6,000,000 IU/mL. All 34 patients (100%) achieved SVR4-HCV RNA negative 4 weeks post-treatment. One patient discontinued the study prematurely at treatment week 4 due to a death – not related to the study drug. The most common side effects were fatigue (18%), diarrhea (9%), and cough (9%). 

The Bottom Line
All of the patients achieved SVR4 – good early results and it will be interesting to find out if eight weeks of treatment can achieve a durable cure.    

Editorial Comment

This is small early study with very encouraging results. It will be interesting to see if similar results can be replicated in a larger population of people across all genotypes.

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